Functional Anatomy of the Sleep-Wakefulness Cycle: Wakefulness
Wakefulness is a necessary, active and periodic brain state, with a circadian and homeostatic regulation and precisely meshed with other states into the sleep-wakefulness cycle. This monograph first overviews the historical background and current understanding of the neuronal systems generating and/...
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| Otros Autores: | , |
| Formato: | Libro electrónico |
| Idioma: | Inglés |
| Publicado: |
Berlin, Heidelberg :
Springer Berlin Heidelberg
2011.
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| Colección: | Advances in Anatomy, Embryology and Cell Biology ;
208. Springer eBooks. |
| Acceso en línea: | Conectar con la versión electrónica |
| Ver en Universidad de Navarra: | https://innopac.unav.es/record=b32890941*spi |
| Sumario: | Wakefulness is a necessary, active and periodic brain state, with a circadian and homeostatic regulation and precisely meshed with other states into the sleep-wakefulness cycle. This monograph first overviews the historical background and current understanding of the neuronal systems generating and/or maintaining the various phases of the sleep-wakefulness cycle. A key cellular correlate of wakefulness is a sustained mode of high activity and plasticity in the closely intertwined circuits of the cortex and thalamus, the 2thalamo-cerebral cortex unity3. The second part of the monograph provides an in-depth review of recent advances on the anatomy, physiology and neurochemistry of the neuronal groups known to drive the 2thalamo-cerebral cortex unity3 into their wakefulness mode, and to keep them in such mode. Interestingly, these neuronal groups are located in the brainstem, hypothalamus or basal forebrain; collectively, they are known as the 2ascending reticular activating system3. Neurotransmitter-specific pathways arising from these neuronal groups target the thalamus and cortex. The various neurotransmitters interact on postsynaptic cortical or thalamic cells to fine-tune their excitability and plasticity, exerting powerful influences on the perceptual and cognitive processes as well as attentional, emotional, motivational, behavioral and arousal states. In turn, corticofugal axons reach the neuronal groups of the 2ascending reticular activating system3, and thus the awake 2thalamo-cerebral cortex unity3 is in position to modulate their activity. |
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| Descripción Física: | XII, 130p. 53 il., 11 il. col |
| Formato: | Forma de acceso: World Wide Web. |
| ISBN: | 9783642146268 |
