Phosphoinositide 3-kinase in Health and Disease Volume 1
From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in pro...
| Autor Corporativo: | |
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| Otros Autores: | , , |
| Formato: | Libro electrónico |
| Idioma: | Inglés |
| Publicado: |
Berlin, Heidelberg :
Springer Berlin Heidelberg
2011.
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| Colección: | Current Topics in Microbiology and Immunology ;
346. Springer eBooks. |
| Acceso en línea: | Conectar con la versión electrónica |
| Ver en Universidad de Navarra: | https://innopac.unav.es/record=b32693941*spi |
Tabla de Contenidos:
- PI3K – From the Bench to the Clinic and Back
- PI3K Book Introduction
- PDK1: The major transducer of PI 3-Kinase actions
- Protein Kinase B (PKB/Akt), a key mediator of the PI3K signaling pathway
- Regulatory subunits of class IA PI3K
- The Regulation of Class IA PI 3-kinases by Inter-Subunit Interactions
- Phosphoinositide signalling pathways in metabolic regulation
- Role of RAS in the regulation of PI 3-kinase
- More than just kinases: The scaffolding function of PI3K
- PI3K signalling in neutrophils
- PI 3-kinase p110beta regulation of platelet integrin alphaIIbbeta3
- PI3Ks in lymphocyte signalling and development
- PI3 kinase regulation of skeletal muscle hypertrophy and atrophy
- Taking PI3Kdelta and PI3Kgamma one step ahead – Dual active PI3Kdelta/gamma inhibitors for the treatment of immune-mediated inflammatory diseases
- Oncogenic Mutations of PIK3CA in Human Cancers
- Structural Effects of Oncogenic PI3Kalpha Mutations
- Comparing the roles of the p110alpha and p110beta isoforms of PI3K in signaling and cancer
- Phosphatidylinositol 3-kinase (PI3K): The oncoprotein
- AKT Signaling in Physiology and Disease
- Faithfull modeling of PTEN loss driven diseases in the mouse
- PI3K as a target for therapy in haematological malignancies
- Clinical development of Phosphatidylinositol-3 kinase pathway inhibitors
- New inhibitors of the PI3K-Akt-mTOR pathway: Insights into mTOR signaling from a new generation of Tor kinase domain inhibitors (TORKinibs)
- Small molecule inhibitors of the PI3-kinase family
- Targeting the RTK-PI3K-mTOR axis in malignant glioma: overcoming resistance
- Subject index.
