Cellular Senescence in Health, Disease and Aging: Blessing or Curse?

Dear Colleagues, When Hayflick and Moorhead coined the term “cellular senescence” (CS) almost 60 years ago, this phenomenon was understood as a mechanism, usually induced by activation of the DNA-repair machinery, to prevent uncontrolled proliferation. Meanwhile, additional beneficial roles for CS h...

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Detalles Bibliográficos
Otros Autores:	Riessland, Markus (Editor )
Formato:	Libro electrónico
Idioma:	Inglés
Publicado:	Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
Materias:	Research & information: general Biology, life sciences γH2AX Alzheimer's disease DNA damage mild cognitive impairment senescence secreted protein acidic and rich in cysteine regeneration homeostasis cellular senescence biology of aging neurodegeneration brain geroscience senolytics tauopathy cancer stress response post-mitotic neuronal senescence amyotrophic lateral sclerosis senescence-associated secretory phenotype (SASP) cell-cycle melanoma pancreatic adenocarcinoma tumor infiltration chemotherapy resistance prostate inflammation AIM2 inflammasome POP3
Ver en Biblioteca Universitat Ramon Llull:	https://discovery.url.edu/permalink/34CSUC_URL/1im36ta/alma991009654241306719