AIM2 inflammasome Alzheimer's disease Biology, life sciences DNA damage POP3 Research & information: general amyotrophic lateral sclerosis biology of aging brain cancer cell-cycle cellular senescence chemotherapy resistance geroscience homeostasis inflammation melanoma mild cognitive impairment neurodegeneration neuronal senescence pancreatic adenocarcinoma post-mitotic prostate regeneration secreted protein acidic and rich in cysteine senescence senescence-associated secretory phenotype (SASP) senolytics stress response tauopathy