Transcriptional control of neural crest development
The neural crest is a remarkable embryonic population of cells found only in vertebrates and has the potential to give rise to many different cell types contributing throughout the body. These derivatives range from the mesenchymal bone and cartilage comprising the facial skeleton, to neuronal deriv...
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| Formato: | Libro electrónico |
| Idioma: | Inglés |
| Publicado: |
[San Rafael, Calif.?] :
Morgan & Claypool
2010.
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| Colección: | Colloquium series on developmental biology ;
#1. |
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| Ver en Biblioteca Universitat Ramon Llull: | https://discovery.url.edu/permalink/34CSUC_URL/1im36ta/alma991009622251206719 |
| Sumario: | The neural crest is a remarkable embryonic population of cells found only in vertebrates and has the potential to give rise to many different cell types contributing throughout the body. These derivatives range from the mesenchymal bone and cartilage comprising the facial skeleton, to neuronal derivatives of the peripheral sensory and autonomic nervous systems, to melanocytes throughout the body, and to smooth muscle of the great arteries of the heart. For these cells to correctly progress from an unspecified, nonmigratory population to a wide array of dynamic, differentiated cell types--some of which retain stem cell characteristics presumably to replenish these derivatives-- requires a complex network of molecular switches to control the gene programs giving these cells their defining structural, enzymatic, migratory, and signaling capacities. This review will bring together current knowledge of neural crest-specific transcription factors governing these progressions throughout the course of development. A more thorough understanding of the mechanisms of transcriptional control in differentiation will aid in strategies designed to push undifferentiated cells toward a particular lineage, and unraveling these processes will help toward reprogramming cells from a differentiated to a more naive state. |
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| Notas: | Part of: Colloquium digital library of life sciences. Series from website. |
| Descripción Física: | 1 online resource (246 p.) Also available in print |
| Bibliografía: | Includes bibliographical references. |
| ISBN: | 9781615040490 |
