ACE-inhibitory activity COVID-19 Humanities PPARγ Social interaction analysis anti-inflammatory anti-obesity anticancer antimicrobial activities antinausea antiobesity antioxidant antioxidant activity antioxidant potential apitherapy bee pollen beverages bioaccessibility bioactive compounds bioactive peptides bioavailability biologic activity biological activities body composition brewing method calafate juice carotenoid central composite rotatable design content