Therapeutic targeting of RAS mutant cancers
The KRAS oncogene is believed to be the most common single nucleotide variant oncogene in human cancer. Historically, efforts to target KRAS and the other RAS GTPases have struggled. More recently, efforts have focused on identifying and exploiting features unique to specific oncogenic mutations. T...
| Autor principal: | |
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| Otros Autores: | , |
| Formato: | Libro electrónico |
| Idioma: | Inglés |
| Publicado: |
Cambridge, United Kingdom ; New York, NY :
Cambridge University Press
2022.
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| Colección: | CUP ebooks.
Cambridge elements. Elements in molecular oncology. |
| Acceso en línea: | Conectar con la versión electrónica |
| Ver en Universidad de Navarra: | https://innopac.unav.es/record=b47029353*spi |
Tabla de Contenidos:
- RAS Biology
- Oncogenic RAS
- RAS Targeting
- Downstream Targeting
- Upstream Targeting
- Targeting Specific RAS Mutants
- KRAS G12 C Targeting
- Direct Targeting of Other RAS Proteins
- KRAS G12R Pancreatic Cancer
- KRAS G13D Colorectal Cancer.
