An introduction to medicinal chemistry
"For many people, taking some form of medication is part of everyday life, whether for mild or severe illness, acute or chronic disease, to target infection or to relieve pain. However for most it remains a mystery as to what happens once the drug has been taken into the body: how do the drugs...
| Otros Autores: | |
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| Formato: | Libro |
| Idioma: | Inglés |
| Publicado: |
Oxford, United Kingdom :
Oxford University Press
2017
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| Edición: | Sixth edition |
| Materias: | |
| Ver en Universidad de Navarra: | https://innopac.unav.es/record=b46393572*spi |
Tabla de Contenidos:
- Drugs and drug targets : an overview. Drug targets. Protein structure and function
- Enzymes : structure and function
- Receptors : structure and function
- Receptors and signal transduction
- Nucleic acids : structure and function
- Pharmacodynamics and pharmacokinetics. Enzymes as drug targets
- Receptors as drug targets
- Nucleic acids as drug targets
- Miscellaneous drug targets
- Pharmacokinetics and related topics
- Case study 1 : statins
- Drug discovery, design, and development. Drug discovery : finding a lead
- Drug design : optimizing target interactions
- Drug design : optimizing access to the target
- Getting the drug to market
- Case study 2 : the design of ACE inhibitors
- Case study 3 : artemisinin and related antimalarial drugs
- Case study 4 : the design of oxamniquine
- Tools of the trade. Combinatorial and parallel synthesis
- Computers in medicinal chemistry
- Quantitative structure-activity relationships (QSAR)
- Case study 5 : design of a thymidylate synthase inhibitor
- Selected topics in medicinal chemistry. Antibacterial agents
- Antiviral agents
- Anticancer agents
- Cholinergics, anticholinergics, and anticholinesterases
- Drugs acting on the adrenergic nervous system
- The opioid analgesics
- Anti-ulcer agents
- Cardiovascular drugs
- Case study 6 : steroidal anti-inflammatory agents
- Case study 7 : current research into antidepressant agents
- Case study 8 : the design and development of aliskiren
- Case study 9 : factor Xa inhibitors
- Case study 10 : reversible inhibitors of HCV NS3-4A protease
- Appendix 1 : essential amino acids
- Appendix 2 : the standard genetic code
- Appendix 3 : statistical data for QSAR
- Appendix 4 : the action of nerves
- Appendix 5 : microorganisms
- Appendix 6 : trade names and drugs
- Appendix 7 : hydrogen bonding interactions
