Textbook of hemophilia
The editors have included new authors and topics, and several chapters from second edition have been dropped. The overall organisation of the textbook has been changed in the light of changes of emphasis over the past 10 years. References have been restricted to create an overall succinct and compre...
| Otros Autores: | , , |
|---|---|
| Formato: | Libro electrónico |
| Idioma: | Inglés |
| Publicado: |
Chichester, West Sussex :
Wiley Blackwell
2014.
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| Edición: | Third edition |
| Colección: | Wiley ebooks.
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| Acceso en línea: | Conectar con la versión electrónica |
| Ver en Universidad de Navarra: | https://innopac.unav.es/record=b46121584*spi |
Tabla de Contenidos:
- Cover; Title page; Copyright page; Contents; Contributors; Historical introduction; Early history; Treatment; Human immunodeficiency virus; Hepatitis C virus; New products; Variant Creutzfeldt-Jakob disease; The future; Notes on this edition; References; PART I: Introduction; CHAPTER 1: Overview of hemostasis; Introduction; Importance of complex assembly to coagulation; Extrinsic pathway to blood coagulation; Attenuation of the procoagulant response; Conclusion; Acknowledgment; References; CHAPTER 2: Cellular processing of factor VIII and factor IX; Factor VIII and hemophilia A.
- Proteolytic processingSummary; Acknowledgments; References; PART II: Hemophilia A; CHAPTER 3: Molecular basis of hemophilia A; Introduction; Structure and function of the factor VIII gene (F8) and protein; F8 gene; Production of factor VIII protein; F8 gene defects found in hemophilia A; Gene rearrangements; Single-base substitutions in the F8 gene; Sequence insertions and deletions; Conclusion; Public database; Mutation nomenclature; Disease severity; References; CHAPTER 4: Prophylaxis; Rationale for prophylaxis; Introduction of prophylaxis; Prophylaxis in children; When to start prophylaxis.
- Prophylaxis in adultsProphylaxis versus on-demand therapy: issues of cost-effectiveness; Optimal treatment regimen for prophylaxis; Future issues in prophylaxis; Conclusion; References; PART III: Inhibitors to factor VIII; CHAPTER 5: Inhibitors to factor VIII: immunology; Introduction; Homeostasis of the antifactor VIII immune response; Lessons from animal models; Clinical observations; Characterization of antifactor VIII antibodies; Factor VIII-specific T cells; Future perspectives; References; CHAPTER 6: Genetic and environmental risk factors for factor VIII inhibitor development.
- IntroductionGenetic factors; Type of causative mutation; Major histocompatibility complex; Immune-regulatory molecules; Environmental factors; Factor concentrate-related factors; Conclusion; References; CHAPTER 7: Epidemiology of inhibitors in hemophilia; Introduction; Definitions of epidemiology terms; Definitions relating to inhibitor terms; Assessing inhibitor epidemiology in hemophilia; Inhibitor prevalence; Hemophilia A; Hemophilia B; Inhibitor incidence in previously untreated patients; Hemophilia A; Hemophilia B; Inhibitor incidence in previously treated patients.
