Pharmacology of the WNT Signaling System
This book reflects the state of the art of our understanding of the WNT signaling system, which comprises a network of signaling pathways initiated by the secreted WNT lipoglycoproteins, which are crucial for embryonal development, stem cell regulation, tissue homeostasis and repair. Dysfunction of...
| Autor Corporativo: | |
|---|---|
| Otros Autores: | , |
| Formato: | Libro electrónico |
| Idioma: | Inglés |
| Publicado: |
Cham :
Springer International Publishing
2021.
|
| Edición: | 1st ed. 2021. |
| Colección: | Springer eBooks.
Handbook of Experimental Pharmacology, 269. |
| Acceso en línea: | Conectar con la versión electrónica |
| Ver en Universidad de Navarra: | https://innopac.unav.es/record=b45847897*spi |
Tabla de Contenidos:
- Pharmacological thinking in WNT signaling
- Controlling WNT Signaling Specificity and implications for targeting WNTs pharmacologically
- WNTs on exosomes
- Strategies to target LRPs in WNT signaling
- Targeting the receptor tyrosine kinase ROR1 by small molecules
- Assessing WNT binding and Frizzled activation employing genetically encoded, biophysical sensors
- Disheveled proteins as crucial mediators of WNT signaling
- Destruction complex and regulation of CTNNB1
- Strategies to therapeutically target WNT/PCP like signaling in disease
- Mining natural compounds to target WNT signaling - from mushrooms to corals
- FZD7 as a therapeutic target in intestinal cancer
- Targeting oncogenic WNT signaling with WNT derived peptides
- Targeting WNT signaling in lung pathology
- The role of WNT signaling in osteoarthritis and the therapeutic potential of its pharmacological targeting
- WNT signaling in Alzheimers disease and other neurodegenerative disorders - opportunities for therapy?
- Targeting WNT signaling as a risk.
