Handbook of polymers for pharmaceutical technologies
| Otros Autores: | , |
|---|---|
| Formato: | Libro electrónico |
| Idioma: | Inglés |
| Publicado: |
Hoboken, New Jersey : Salem, Massachusetts :
John Wiley & Sons ; Scrivener Publishing LLC
[2015]
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| Acceso en línea: | Conectar con la versión electrónica |
| Ver en Universidad de Navarra: | https://innopac.unav.es/record=b37656752*spi |
Tabla de Contenidos:
- Cover; Title Page; Copyright Page; Dedication; Contents; Preface; 1 Gellan as Novel Pharmaceutical Excipient; 1.1 Introduction; 1.2 Structural Properties of Gellan; 1.3 Physiochemical Properties of Gellan; 1.3.1 Gelling Features and Texture Properties; 1.3.2 Rheology; 1.3.3 Biosafety and Toxicological Studies; 1.4 Pharmaceutical Applications of Gellan; 1.4.1 Gellan-Based Pharmaceutical Formulations; 1.4.1.1 Gel Formulations; 1.4.1.2 Mucoadhesive Formulations; 1.4.1.3 Granulating/Adhesive Agents and Tablet Binders; 1.4.1.4 Controlled Release Dosage Form; 1.4.1.5 Microspheres and Microcapsules.
- 1.4.1.6 Gellan Beads1.4.1.7 Gellan Films; 1.4.1.8 Gellan Nanohydrogels; 1.4.1.9 Gellan Nanoparticles; 1.4.2 Role of Gellan Excipients in Drug Delivery and Wound Healing; 1.4.2.1 Ophthalmic Drug Delivery; 1.4.2.2 Nasal Drug Delivery; 1.4.2.3 Oral Drug Delivery; 1.4.2.4 Buccal Drug Delivery; 1.4.2.5 Periodontal Drug Delivery; 1.4.2.6 Gastrointestinal Drug Delivery; 1.4.2.7 Vaginal Drug Delivery; 1.4.2.8 Colon Drug Delivery; 1.4.2.9 Wound Healing; 1.5 Conclusion and Future Perspectives; References; 2 Application of Polymer Combinations in Extended Release Hydrophilic Matrices.
- 2.1 Extended Release Matrices2.1.1 Polymers Used in ER Matrices; 2.1.2 Water-Soluble (Hydrophilic) Polymers; 2.1.3 Water-Insoluble Polymers; 2.1.4 Fatty Acids/Alcohols/Waxes; 2.2 Polymer Combinations Used in ER matrices; 2.2.1 Compatibility and Miscibility of Polymers; 2.2.2 Combination of Non-Ionic Polymers; 2.3 Combination of Non-Ionic with Ionic Polymers; 2.4 Combinations of Ionic Polymers; 2.5 Other Polymer Combinations; 2.6 Effect of Dissolution Method (Media) on Drug Release from ER Matrices Containing Polymer Combinations.
- 2.7 Main Mechanisms of Drug-Polymer and/or Polymer-Polymer Interaction in ER Formulations2.8 Summary and Conclusions; References; 3 Reagents for the Covalent Attachment of mPEG to Peptides and Proteins; 3.1 Introduction; 3.2 General Considerations about PEG Reagents and PEGylation Reactions; 3.3 PEGylation of Amino Groups; 3.3.1 PEGylation by Urethane Linkage Formation; 3.3.2 PEGylation by Amide Linkage Formation; 3.3.3 PEGylation by Reductive Amination; 3.3.4 PEGylation by Alkylation; 3.4 PEGylation of Thiol Groups; 3.5 Reversible PEGylation; 3.6 Enzymatic PEGylation.
- 3.7 PEGylation of Carbohydrates Residues3.8 PEGylation by Click Chemistry; 3.9 Other PEGylations; 3.9.1 PEGylation at Arginine; 3.9.2 PEGylation at Tirosine; 3.9.3 PEGylation at Histidine; 3.9.4 PEGylation at Carboxylic Groups; 3.9.5 PEGylation with mPEG Isothiocyanate; 3.10 Actual Trends; 3.11 Conclusions; Acknowledgements; References; 4 Critical Points and Phase Transitions in Polymeric Matrices for Controlled Drug Release; 4.1 Introduction; 4.2 Matrix Systems; 4.2.1 Inert Matrices; 4.2.2 Hydrophilic Matrices; 4.2.3 Lipidic Matrices.
