Disordered Vertebral and Rib Morphology in Pudgy Mice : Structural Relationships to Human Congenital Scoliosis

Disordered Vertebral and Rib Morphology in Pudgy Mice Structural Relationships to Human Congenital Scoliosis

This book presents results obtained from the whole mount preparations, radiological, and histological studies of 60 pu/pu and pu/+ mice from late embryo until 3 months of age. Most mice were in the embryo to 6 week age group where vertebral developmental changes are most marked. Although vertebral a...

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Detalles Bibliográficos
Autor principal: Shapiro, Frederic (-)
Autor Corporativo: SpringerLink (-)
Formato: Libro electrónico
Idioma:Inglés
Publicado: Cham : Springer International Publishing : Imprint: Springer 2016.
Colección:Advances in Anatomy, Embryology and Cell Biology, 221.
Springer eBooks.
Acceso en línea:Conectar con la versión electrónica
Ver en Universidad de Navarra:https://innopac.unav.es/record=b34532808*spi
Tabla de Contenidos:
  • I. INTRODUCTION
  • II. MATERIALS AND METHODS
  • 1. Source, distribution, and ages of pudgy and non-affected mice. - 2. Whole mount preparations
  • 3. Radiographic studies
  • 4. Histologic studies
  • 5. Computerized three-dimensional reconstructions
  • 6. Previous studies on chick vertebral development and human congenital scoliosis
  • III. RESULTS
  • 1. Gross appearance
  • 2. Whole mount appearances
  • 3. Radiographic studies
  • 4. Histology studies: vertebrae, ribs, intervertebral discs and ganglia
  • 5. Computerized three-dimensional reconstructions
  • 6. Chick embryo vertebral development
  • 7. Radiology and histopathology of human congenital scoliosis spine
  • IV. DISCUSSION
  • ion
  • 3. The pudgy mouse
  • 4. Genetic influences on axial development; mutations identified in mouse models with vertebral deformation
  • 5. Congenital scoliosis (human); its similarity with pudgy mouse vertebral abnormalities
  • 6. Pathogenesis of pudgy and human congenital scoliosis based on histopathologic studies.-V. CONCLUSIONS
  • 1. Implications of pudgy vertebral abnormalities for biologic research
  • 2. Implications of pudgy vertebral abnormalities for clinical patient treatment. .

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