Prions and prion diseases new developments
| Otros Autores: | |
|---|---|
| Formato: | Libro electrónico |
| Idioma: | Inglés |
| Publicado: |
New York :
Nova Science
cop. 2012.
|
| Colección: | Protein biochemistry, synthesis, structure, and cellular functions series.
Protein science and engineering. |
| Acceso en línea: | Conectar con la versión electrónica |
| Ver en Universidad de Navarra: | https://innopac.unav.es/record=b33907523*spi |
Tabla de Contenidos:
- PRIONS AND PRION DISEASES; PRIONS AND PRION DISEASES; CONTENTS ; PREFACE ; NEUROPATHOLOGY OF HUMAN PRION DISEASES ; ABSTRACT ; INTRODUCTION ; THE ROLE OF NEUROPATHOLOGY ; PERFORMING THE AUTOPSY ; NEUROPATHOLOGICAL EXAMINATION; A.) Macroscopy; B.) Work-Up for Histological Evaluation ; C.) Microscopic Assessment ; I.) Spongiform Change of the Neuropil ; a) In Sporadic Forms; b.) In Genetic Forms ; c.) In Acquired Forms ; II) Neuronal Death ; a.) In Sporadic Forms ; b.) In Genetic Forms ; c.) In Acquired Forms.
- SYNAPTIC PATHOLOGY III.) Astroglial Proliferation ; IV.) Microglial Activation ; V.) PrP Amyloid Plaques ; a.) In Sporadic Forms ; b.) In Genetic Forms ; c.) In Acquired Forms ; VI.) Cerebellar Pathology ; a.) In Sporadic Forms ; b.) In Genetic Forms ; c.) In Acquired Forms; RELATIVE RESISTANCE OF HIPPOCAMPUS IN CJD ; VII.) Detection of PrP ; VIIa.) By Immunohistochemistry ; a.) In Sporadic Forms ; b.) In Genetic Forms ; c.) In Acquired Forms ; VIIb.) By histoblot and Paraffin-Embedded Tissue Blot.
- VIId.) By Western blota.) In Sporadic Forms ; b.) In Genetic Forms ; c.) In Acquired Forms ; VIII.) Co-deposition of other Abnormal Protein Aggregates in CJD ; a) In Sporadic Forms ; b) In Genetic Forms ; c) In Acquired Forms ; IX.) Differential Diagnoses from Autopsy Series ; X.) Neuronal Systems and Their Clinico-Pathological Correlates ; CONCLUSION ; ACKNOWLEDGMENTS ; REFERENCES ; THE NATURE OF THE INFECTIOUS AGENTS: PRP MODELS OF RESISTANT SPECIES TO PRION DISEASES (DOG, RABBIT AND HORSES); Abstract; 1. Introduction.
- 2. MaterialsandMethods3. ResultsandDiscussion; 4. Conclusion; Acknowledgments; References; INDUCING TRANSMISSIBLE PRION DISEASES WITH RECOMBINANT FIBRILS: A NEW CONCEPT ON GENESIS AND EVOLUTION OF INFECTIOUS PRIONS ; ABSTRACT ; GENERATING TRANSMISSIBLE PRION DISEASES DE NOVO ; THE MECHANISM OF TRIGGERING PRION DISEASE BY RPRP AMYLOID FIBRILS ; EXPERIMENTAL EVIDENCE SUPPORT THE SECOND MODEL ; THE HYPOTHESIS OF DEFORMED TEMPLATING ; CONFORMATIONAL SWITCHING WITHIN INDIVIDUAL AMYLOID FIBRILS AND STRAIN ADAPTATION PHENOMENON.
- CROSS-TALK BETWEEN AMYLOIDOGENIC PROTEINS REFERENCES ; SYNTHETIC PRIONS ; ABSTRACT; 1. INTRODUCTION ; 2. STRATEGIES FOR DE NOVO MAMMALIAN PRIONS GENERATION ; 2.1. Cell-Free Assay Using Mammalian Prions ; 2.2. De Novo Generation of Prions by Mouse Transgenesis ; 2.3. In Vitro De Novo Prions by PMCA ; 2.4. De Novo Prions by Amyloid Seeding Assay ; 2.5. De Novo Prions by Annealing Technique ; 2.6. Concluding Remarks and New Emerging Techniques for Prion Detection and Generation ; 3. STRUCTURAL BIOLOGY OF NATURAL AND SYNTHETIC PRIONS.
