The Tumor Immunoenvironment
Interaction between malignant cells and their surrounding tissue plays a crucial role in tumor growth, invasiveness and spreading to the distant organs. New findings provide evidence of a principal importance of the immune cells for controlling this interaction and orchestrating multiple events in t...
| Autor Corporativo: | |
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| Otros Autores: | , , |
| Formato: | Libro electrónico |
| Idioma: | Inglés |
| Publicado: |
Dordrecht :
Springer Netherlands
2013.
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| Colección: | Springer eBooks.
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| Acceso en línea: | Conectar con la versión electrónica |
| Ver en Universidad de Navarra: | https://innopac.unav.es/record=b33008279*spi |
Tabla de Contenidos:
- Preface
- Introduction
- Role of the immunological environment in cancer initiation, development and progression
- Part I Tumor Microenvironment and Immunoenvironment
- The metastatic microenvironment
- Tumor infiltration by immune cells: pathologic evaluation and a clinical significance
- Immunologic interpretation of cancer biology: impact on clinical outcome
- Part II Developmental Characteristics of the Tumor ImmunoEnvironment
- Development of antitumor cellular immunity
- The versatile world of inflammatory chemokines in cancer.-Inflammation, Tumor Progression, and Immune Suppression
- Pleiotropic and differential functions of IL-1a and IL-1b shape the tumor microenvironment and affect the outcome of malignancies
- Impact of obesity and aging on the tumor immunoenvironment
- Part III Tumor Escape from Immune Recognition
- MHC class I antigens and the tumor microenvironment
- Tumor-produced immune regulating factors
- Roles of signaling pathways in cancer cells and immune cells in generation of immunosuppressive tumor-associated microenvironments.- T cell malfunction in the tumor environment
- Signaling of tumor-induced immunosuppression of dendritic cells
- Tumor microenvironment may shape the function and phenotype of NK cells through the induction of split anergy and generation of regulatory NK cells
- Part IV Immune Regulators in the Tumor ImmunoEnvironment
- The role of myeloid-derived suppressor cells in cancer
- Macrophage differentiation and activation states in the tumor microenvironment
- Dendritic cells and cancer: development, dysfunction and therapeutic targets
- The role of tumor-associated neutrophils in cancer
- Mast cell modulation of the tumor microenvironment
- Regulatory T cells in patients with cancer
- Tumor-evoked regulatory B cells as important mediators of cancer escape
- Part V Tumor Escape and Cancer Immunotherapy
- Cancer immunotherapy: Overview in brief
- Programming of MDSC: New opportunities for targeted therapy
- Therapeutic targeting regulatory T cells in tumor.-ChemoImmunoModulation: Focus on myeloid regulatory cells
- Combining vaccines with therapies that render tumor cells more susceptible to immune mediated killing
- Prophylactic Cancer Vaccines
- Part VI Analyzing Immune Responses in Cancer
- Approaches to Immunologic Monitoring of Clinical Trials
- Evaluation of the tumor immunoenvironment in clinical trials
- Analysis of Myeloid-derived Suppressor Cells in Patients with Cancer
- When results of T cell immune monitoring match or do not match clinical outcomes of tumor vaccine trials - what more could and should we measure?
