Advances in Bacterial Pathogen Biology
This volume is an up-to-date overview of the physiology of selected pathogenic bacteria. Each chapter is written by experts in the field of that organism.The focus is on biochemistry and physiology but topics of clinical relevance are included. Key features: Contributions from leading authorities. I...
| Otros Autores: | |
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| Formato: | Libro electrónico |
| Idioma: | Inglés |
| Publicado: |
San Diego :
Academic Press
2014.
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| Colección: | Science Direct e-books.
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| Acceso en línea: | Conectar con la versión electrónica |
| Ver en Universidad de Navarra: | https://innopac.unav.es/record=b30555619*spi |
Tabla de Contenidos:
- Front Cover; Advances in Bacterial PathogenBiology; Copyright; Contents; Contributors; Chapter One: Energetics of Pathogenic Bacteria and Opportunities for Drug Development; 1. Introduction; 2. Bacterial Energetics as a Target Space for Drug Development; 2.1. Generation of the proton motive force: An essential property of all bacterial cells; 2.2. Diversity and flexibility of electron transport chains in bacteria; 2.3. Primary respiratory dehydrogenases; 2.3.1. NADH dehydrogenases: The roles of bacterial NDH-1 and NDH-2.
- 2.3.2. Succinate dehydrogenase: Enzyme variation and essentiality in bacterial pathogens2.3.3. Formate dehydrogenase: A major electron donor for anaerobic respiratory chains; 2.3.4. Hydrogenase: Consuming a dependable reduced gas; 2.4. Terminal respiratory reductases; 2.4.1. Haem-copper terminal oxidases: Proton translocation at a range of oxygen partial pressures; 2.4.2. Cytochrome bd oxidase: A bacterial-specific next-generation drug target; 2.4.3. Respiratory nitrate and nitrite reductases: Exploiting host immune defences.
- 2.4.4. Fumarate reductase: Anaerobic respiration using an endogenous electron acceptor2.4.5. Tetrathionate reductase and other alternative reductases: Emerging roles in host colonisation; 2.5. Generators of sodium motive force in bacterial pathogens; 2.6. ATP homeostasis and the F1Fo-ATP synthase: A clinically approved drug target; 3. Conclusions and Future Perspectives; Acknowledgements; References; Chapter Two: The Impact of Horizontal Gene Transfer on the Biology of Clostridium difficile; 1. Introduction to Clostridium difficile and CDI; 2. Introns; 3. IStrons; 4. Mobilisable Transposons.
- 5. Conjugative Transposons5.1. Tn916-like elements; 5.2. Tn1549-like elements; 6. Other Integrative MGEs in C. difficile; 7. The skinCd Element; 8. Bacteriophages; 9. Transfer of the PaLoc; 10. Conclusions; References; Chapter Three: Metal Ion Homeostasis in Listeria monocytogenes and Importance in Host-Pathogen Interactions; 1. Introduction; 2. Overview of Listeria monocytogenes Disease Progression; 2.1. The intracellular life cycle of L. monocytogenes; 3. Control of Metal Levels in Bacteria; 4. L. monocytogenes and Zinc; 4.1. Zinc availability within the host.
- 4.1.1. Extracellular zinc chelation4.1.2. Control of intracellular zinc availability; 4.2. Zinc sensing and homeostasis in L. monocytogenes; 4.2.1. The Zur regulon; 4.2.2. Zinc import by the ZurLAM and ZinABC systems; 4.2.3. Other proteins with a role in zinc import; 4.2.4. The response to elevated zinc and zinc export; 5. L. monocytogenes and Copper; 5.1. Exploiting the microbicidal activity of copper in host immune defences; 5.2. Copper sensing and homeostasis in L. monocytogenes; 5.2.1. Copper efflux mediated by the csoR-copA-copZ operon; 6. Concluding Remarks; References.
