Guidelines on the management of latent tuberculosis infection
These new guidelines supersede previous WHO policy documents on the management of LTBI (Latent Tuberculosis Infection) in people living with HIV, household contacts of people with active TB, other groups at risk of developing TB, and for LTBI testing. The consolidated guidelines are expected to prov...
| Autor principal: | |
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| Autor Corporativo: | |
| Formato: | Libro electrónico |
| Idioma: | Inglés |
| Publicado: |
Geneva, Switzerland :
World Health Organization, Global TB Programme
2018.
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| Materias: | |
| Ver en Biblioteca Universitat Ramon Llull: | https://discovery.url.edu/permalink/34CSUC_URL/1im36ta/alma991009816713106719 |
Tabla de Contenidos:
- Executive summary
- A. Identification of at-risk populations for LTBI testing and treatment
- B. Algorithms to rule out active TB disease
- C. Testing for LTBI
- D. Treatment options for LTBI
- E. Preventive treatment for contacts of patients with multidrug-resistant-TB
- 1. Introduction
- 1.1. Background
- 1.2. Rationale
- 1.3. Scope
- 1.4. Target
- 1.5. Development of the guidelines
- 1.6. Quality of evidence and strength of the recommendations
- 1.7. Publication, implementation, evaluation and expiry
- 1.8. Presentation of the guidelines and recommendations
- 2. Identification of populations for testing and treatment of latent tuberculosis infection
- 2.1. Adults and adolescents living with HIV
- 2.2. Infants and children living with HIV
- 2.3. HIV-negative household contacts of a person with pulmonary TB
- 2.4. Other HIV-negative at-risk groups
- 3. Algorithms for ruling out active tuberculosis disease
- 3.1. Adults, adolescents, children and infants living with HIV
- 3.2. HIV-negative infants, children and adults who are household contacts of a person with pulmonary TB
- 3.3. Considerations for implementation
- 4. Testing for latent tuberculosis infection
- Summary of evidence
- Rationale for the recommendations
- Considerations for implementation
- 5. Treatment options for latent tuberculosis infection
- Summary of evidence
- 6. Preventive treatment for contacts of patients with multidrug-resistant tuberculosis
- Summary of evidence
- Rationale for the recommendations
- Considerations for implementation
- 7. Issues in implementation
- 7.1. Ethical considerations
- 7.2. Programme management, monitoring and evaluation
- 8. Research priorities
- 8.1. Risks of at-risk populations for progression to active TB disease
- 8.2. Defining the best algorithm for ruling out active TB
- 8.3. Improved diagnostic tests and performance of LTBI tests in at-risk populations
- 8.4. Treatment options for LTBI
- 8.5. Monitoring of adverse events
- 8.6. Risk of drug resistance following LTBI treatment
- 8.7. Adherence to and completion of treatment
- 8.8. Cost-effectiveness
- 8.9. Preventive treatment for contacts of people with MDR-TB
- 8.10. Programme management
- 9. References
- Annex 1. GRADE profile tables for new recommendations
- Annex 2. Evidence-to-Decision and GRADE tables
- Annex 3. Values and preferences for the management of latent tuberculosis infection: survey of populations affected by the recommendations.
