Therapeutic development in the absence of predictive animal models of nervous system disorders : proceedings of a workshop

Therapeutic development in the absence of predictive animal models of nervous system disorders proceedings of a workshop

"Compared with other disease areas, central nervous system (CNS) disorders have had the highest failure rate for new compounds in advanced clinical trials. Most CNS drugs fail because of efficacy, and the core issue underlying these problems is a poor understanding of disease biology. Concern a...

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Detalles Bibliográficos
Autores Corporativos: Forum on Neuroscience and Nervous System Disorders (-), Board on Health Sciences Policy, Health and Medicine Division, National Academies of Sciences, Engineering, Medicine, Therapeutic Development in the Absence of Predictive Animal Models of Nervous System Disorders : a Workshop
Otros Autores: Bain, Lisa J., rapporteur (rapporteur), Stroud, Clare, rapporteur, Keren, Noam I., rapporteur, Norris, Sheena M. Posey, rapporteur
Formato: Libro electrónico
Idioma:Inglés
Publicado: Washington, District of Columbia : National Academies Press 2017.
Edición:1st ed
Materias:
Nervous system > Diseases > Congresses.
Ver en Biblioteca Universitat Ramon Llull:https://discovery.url.edu/permalink/34CSUC_URL/1im36ta/alma991009622039306719
Tabla de Contenidos:
  • Introduction and overview
  • Drug development for nervous system disorders: overview of challenges and potential opportunities
  • Case studies: therapeutic development for Parkinson's disease and schizophrenia in the absence of predictive animal models of disease
  • New modeling approaches for nervous system disorders
  • Private-sector thresholds for investment in neuroscience clinical trials
  • Ethical considerations
  • Regulatory perspectives
  • Appendix A: References
  • Appendix B: Workshop agenda
  • Appendix C: Registered attendees.

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