Regulation of gastrointestinal mucosal growth
The mammalian gastrointestinal mucosa is a rapidly self-renewing tissue in the body, and its homeostasis is preserved through the strict regulation of epithelial cell proliferation, growth arrest, and apoptosis. The control of the growth of gastrointestinal mucosa is unique and, compared with most o...
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| Otros Autores: | |
| Formato: | Libro electrónico |
| Idioma: | Inglés |
| Publicado: |
San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA) :
Morgan & Claypool
c2011.
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| Colección: | Colloquium digital library of life sciences.
Colloquium series on integrated systems physiology, from molecule to function, # 15. |
| Materias: | |
| Ver en Biblioteca Universitat Ramon Llull: | https://discovery.url.edu/permalink/34CSUC_URL/1im36ta/alma991009622018006719 |
Tabla de Contenidos:
- Introduction
- Intestinal architecture and development
- Mucosal wall architecture
- Development and functions
- Esophagus
- Stomach
- Small intestine
- Large intestine
- Characteristics of gut mucosal growth
- Intestinal stem cells
- ISCs and their niches
- Signaling pathways regulating ISCs
- Wnt signaling pathway
- BMP pathway
- Notch pathway
- Role of GI hormones on the gut mucosal growth
- Gastrin
- Cholecystokinin
- Secretin
- Somatostatin
- Ghrelin
- Bombesin/gastrin-releasing peptide
- Other GI hormones
- Peptide growth factors in GI mucosal growth
- EGF family
- TGF-b family
- IGF family
- FGF family
- Other factors
- Luminal nutrients and microbes in gut mucosal growth
- Luminal factors
- Microbes in health and mucosal growth
- Dietary supplements
- Polyamines in the regulation of mucosal growth
- Polyamine metabolism
- Polyamines stimulate mucosal growth by enhancing gene transcription
- Polyamines regulate epithelial renewal by altering expression of protooncogenes
- Polyamines are required for protooncogene transcription
- Possible mechanisms of action of the polyamines
- Induced mRNA stabilization and growth arrest after polyamine depletion
- Polyamine depletion stabilizes p53
- Polyamines modulate JunD mRNA stability
- Polyamine depletion stabilizes TGF-b mRNA and activates Smad signaling
- Polyamines regulate apoptosis by altering the stability of ATF-2 and XIAP mRNAs
- Polyamines modulate the stability of mRNAs via the RNA-binding protein HuR
- Polyamines modulate subcellular trafficking of HuR
- Induced cytoplasmic HuR binds to target mRNAs in polyamine-deficient cells
- Induced HuR stabilizes its target mRNAs in polyamine-deficient cells
- mRNA translation by polyamines
- Summary and conclusions
- Acknowledgments
- References
- Author biographies.
