Skeletal muscle circulation

The aim of this treatise is to summarize the current understanding of the mechanisms for blood flow control to skeletal muscle under resting conditions, how perfusion is elevated (exercise hyperemia) to meet the increased demand for oxygen and other substrates during exercise, mechanisms underlying...

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Detalles Bibliográficos
Autor principal: Korthuis, Ronald J. (-)
Autor Corporativo: University of Missouri. School of Medicine (-)
Formato: Libro electrónico
Idioma:Inglés
Publicado: [San Rafael, Calif.?] : Morgan & Claypool Life Sciences 2011.
Colección:Colloquium series on integrated systems physiology ; #23.
Materias:
Ver en Biblioteca Universitat Ramon Llull:https://discovery.url.edu/permalink/34CSUC_URL/1im36ta/alma991009621976706719
Tabla de Contenidos:
  • 1. Introduction
  • 2. Anatomy of skeletal muscle and its vascular supply
  • 2.1 Skeletal muscle anatomy
  • 2.2 Vascular anatomy in skeletal muscle
  • 2.3 Lymphatics in skeletal muscle
  • 3. Regulation of vascular tone in skeletal muscle
  • 3.1 Basal hemodynamics
  • 3.2 Basal vascular tone
  • 3.3 Control of vascular smooth muscle (VSM) contraction
  • 3.4 Opening potassium channels induces vasodilation in skeletal muscle
  • 3.5 Transient receptor potential (TRP) channels are cation gates that modulate vascular tone
  • 3.6 Endothelium-dependent mechanisms in the control of VSM contraction
  • 3.7 Intrinsic (local) mechanisms regulating vascular resistance
  • 3.8 Differential control of vasoregulation along the arterial tree
  • 3.9 Local control phenomena in skeletal muscle
  • 3.10 Pericytes and vasomotor control in skeletal muscle
  • 3.11 Mechanical effects of contraction, the muscle pump
  • 3.12 Extrinsic (remote) control of skeletal muscle blood flow
  • 4. Exercise hyperemia and regulation of tissue oxygenation during muscular activity
  • 4.1 Cardiovascular adjustments to exercise
  • 4.2 Matching oxygen and substrate delivery to meet the demand for oxygen and nutrients by active muscles
  • 4.3 Skeletal muscle blood flow is pulsatile during rhythmic exercise
  • 4.4 Skeletal muscle blood flow varies by muscle fiber type composition at rest and exercise
  • 4.5 Postexercise hypotension after prolonged exercise
  • 4.6 Local control mechanisms and the regulation of skeletal muscle blood flow during exercise
  • 4.7 Central control processes influence exercise hyperemia
  • 4.8 Chronic exercise training induces adaptive changes in the skeletal muscle circulation
  • 4.9 Regulation of tissue oxygenation during muscular activity
  • 5. Microvascular fluid and solute exchange in skeletal muscle
  • 5.1 General principles and functions of transcapillary fluid filtration
  • 5.2 Ultrastructural pathways
  • 5.3 Effect of solute charge, size, conformation and microvascular surface area for exchange
  • 5.4 Fluid exchange across the microcirculation
  • 5.5 Transcapillary fluid and solute exchange in skeletal muscle during exercise
  • 5.6 Edema safety factors limit fluid accumulation in skeletal muscles during exercise
  • 5.7 Transendothelial filtration modifies arteriolar, capillary, and venular function
  • 5.8 Fluid flow in the interstitium modifies the function of tissue cells
  • 6. Skeletal muscle circulation in aging and disease states: protective effects of exercise
  • 6.1 Ischemia/reperfusion (I/R) injury
  • 6.2 Hypertension, hypercholesterolemia, obesity, and diabetes
  • 6.3 Portal venous hypertension induces skeletal muscle hyperemia
  • 6.4 Regular physical activity induces a protective phenotype in vascular tissues
  • 6.5 Skeletal muscle blood in aging and the protective effects of exercise
  • References
  • Author biography.