3D-CNN BRATS dataset Kolmogorov-Smirnov hypothesis test MRgFUS Mask R-CNN Medicine RBF neural networks U-Net Wisconsin Breast Cancer Dataset bone scintigraphy brain MRI image brain tumor brain tumor segmentation breast cancer breast cancer detection breast cancer diagnosis breast imaging breast mass classification clutter rejection computer-aided detection contrast source inversion dataset partition deep learning dimensionality reduction ensemble classification ensemble method false positives reduction feature selection image reconstruction