Agelas Alternaria sp Anthocidaris crassispina Chrysosporium lobatum Cladosporium cladosporioides Medicine P. gingivalis acetylcholinesterase agesasines altercrasins antibiotics antimicrobial activity azole-based peptide bioactivity bromopyrrole alkaloid cyanobacteria cytotoxicity decalin derivatives endophytic fungus enzymatic inhibitory activity gene disruption genome mining genome sequencing lobophorin mangrove plant marine fungi marine sponge metabolic engineering methicillin-resistant S. aureus natural product