Antirhea borbonica DESI-imaging ER-stress Medicine Nrf2 pathway PERK Pharmacology UPR anti-inflammatory anti-oxidant anti-viral activity antioxidant enzymes antioxidants caffeic acid cancer prevention curcumin diabetes flavonoids glioblastoma cells inflammation insulin-producing cells kidney fibrosis marine algae mechanism of action mitochondria oxidative stress p53 polyphenols radiation verbascoside