D2EHPA DSPM model Dioscorea hispida DoE Taguchi method Technology: general issues WWTP acid recovery acyl homoserine lactone alkali treatment anaerobic membrane bioreactor anion exchange membrane antibiotic resistance genes antibiotics antifouling aquaporin backwash biofouling calcium calcium sulfate precipitation risk calcium-carboxyl intra-bridging carbon nitride ceramic membrane characterization chitosan chlorine coagulation cobalt(II) counter-transport desalination